Endocrinology Research and Practice
Case Report

A Case of Plurihormonal Pituitary Giant Macroadenoma

1.

Department of Endocrinology, Ege University Faculty of Medicine, İzmir, TURKEY

2.

Department of Pathology, Ege University Faculty of Medicine, İzmir, TURKEY

3.

Department of Radiology, Ege University Faculty of Medicine, İzmir, TURKEY

4.

Department of Neurosurgery, Ege University Faculty of Medicine, İzmir, TURKEY

Endocrinol Res Pract 2021; 25: 227-231
DOI: 10.25179/tjem.2020-78997
Read: 1833 Downloads: 494 Published: 01 June 2021

ABSTRACT

We would like to draw the attention of the readers to Pit-1 positive giant macroadenomas in this work. A 62-year-old male patient was admitted to the hospital due to his vision loss and blurred vision in the left eye. His pituitary magnetic resonance imaging revealed the presence of a diffuse and homogeneous mass lesion originating from the pituitary gland having grade 4 invasion into the bilateral cavernous sinus and eroding the base of the sella. He consulted our department before his operation in 2016. Laboratory examination revealed that pituitary hormone levels were within normal ranges while the testosterone level [total testosterone 0.27 ng/mL (2.8-8)] was low. Pathological findings revealed a pituitary adenoma that displayed focal immunoreactivity to thyrotrophin, growth hormone, and prolactin. While the main prevalence and the basic mechanism of plurihormonal pituitary adenomas are not clear, one of the hypotheses is based on the role of divergent transcription factors such as Pit-1. According to this condition, we should perform a complete biochemical and histologic evaluation in patients with pituitary adenomas.

 

 

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