Turkish Journal of
Endocrinology and Metabolism
Case Report

Adrenocorticotropic Hormon-Secreting Pheochromocytoma: A Rare Cause of Cushing’s Syndrome

1.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey

2.

Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey

3.

Department of General Surgery, Gazi University Faculty of Medicine, Ankara, Turkey

4.

Department of Pathology, Gazi University Faculty of Medicine, Ankara, Turkey

5.

Division of Endocrinology and Metabolism, Yüksek Ihtisas University, Ankara, Turkey

Turk J Endocrinol Metab 2019; 23: 125-129
DOI: 10.25179/tjem.2018-63374
Read: 323 Downloads: 116 Published: 01 June 2019

ABSTRACT

Pheochromocytoma is a rare cause of ectopic Cushing’s syndrome and presents a challenge to the clinician in the diagnosis and treatment. In this study, a rare case of adrenocorticotropic hormone-producing pheochromocytoma is presented. A 55-years-old man with the symptoms of hypercortisolism, multidrug-resistant hypertension, and an adrenal mass is presented. The laboratory results were consistent with hypercortisolism, high plasma adrenocorticotropic hormone, high 24-hour urine metanephrine and normetanephrine and severe hypokalemia. Abdominal computerized tomography showed a 3-cm non-adenoma left adrenal mass. After preoperative management, left adrenalectomy was performed. A histopathological examination revealed a 2.5 cm pheochromocytoma with focal positivity for adrenocorticotropic hormone. The patient was discharged with full recovery under hydrocortisone replacement therapy. Furthermore, six weeks after the operation, 24-hour urinary excretion of metanephrine and normetanephrine was within normal ranges. In conclusion, an adrenocorticotropic hormone-producing pheochromocytoma should be considered in patients with clinical manifestations of ectopic Cushing’s syndrome and adrenal mass.

 

 

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TURKISH
EISSN 1308-9846