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ABSTRACT
Paragangliomas are rarely malignant tumors, and they most commonly accompany medullary thyroid tumors as a part of multiple endocrine neoplasia (MEN) syndro-mes. Rare cases of paraganglioma with papillary thyroid carcinoma, but not follicular carcinoma, has been reported in English literature before. A 52 year-old woman admitted with left-sided neck mass and right pelvic pain. Pathological examination of the surgically excised pelvic mass, which was visualized in pelvic MRI, revealed a paraganglioma which stained positive for NSE, EMA, S-100 and negative for thyro-globulin. The patient also had multinodular goiter and pathology of the dominant nodule in thyroidectomy material, was consistent with follicular carcinoma. The tumor was strongly positive for thyroglobulin and negative for neuroendocrine tumor markers. Metastatic foci of follicular carcinoma and paraganglioma were observed in two bone core biopsies taken from different parts of pelvis. After completion thyroidectomy palliative therapy for bone metastasis was planned.
Paragangliomas are rarely malignant tumors, and they most commonly accompany medullary thyroid tumors as a part of multiple endocrine neoplasia (MEN) syndro-mes. Rare cases of paraganglioma with papillary thyroid carcinoma, but not follicular carcinoma, has been reported in English literature before. A 52 year-old woman admitted with left-sided neck mass and right pelvic pain. Pathological examination of the surgically excised pelvic mass, which was visualized in pelvic MRI, revealed a paraganglioma which stained positive for NSE, EMA, S-100 and negative for thyro-globulin. The patient also had multinodular goiter and pathology of the dominant nodule in thyroidectomy material, was consistent with follicular carcinoma. The tumor was strongly positive for thyroglobulin and negative for neuroendocrine tumor markers. Metastatic foci of follicular carcinoma and paraganglioma were observed in two bone core biopsies taken from different parts of pelvis. After completion thyroidectomy palliative therapy for bone metastasis was planned.