Endocrinology Research and Practice
Case Report

Congenital Adrenal Hyperplasia as a Cause of Secondary Hypertension in Adults: Three Cases Sekonder Hipertansiyon Sebebi Olarak Konjenital Adrenal Hiperplazi: Üç Vaka

1.

Department of Endocrinology, Bahcesehir University Faculty of Medicine, Department of Endocrinology and Metabolism, Istanbul, Turkey

2.

Giresun Ada Hastanesi, Giresun, Turkey

3.

Ordu Devlet Hastanesi, Ordu, Turkey

Endocrinol Res Pract 2019; 23: 135-140
DOI: 10.25179/tjem.2019-65085
Read: 1964 Downloads: 580 Published: 01 June 2019

ABSTRACT

Congenital adrenal hyperplasia is a group of hereditary disorders originating from enzymatic defects in steroidogenesis, resulting in impaired cortisol synthesis in the adrenal cortex. The rare forms of congenital adrenal hyperplasia characterized by hypertension and hypokalemia include 11- β and 17-α hydroxylase deficiencies. We described three cases of congenital adrenal hyperplasia, two with 11-β hydroxylase and one with 17-α hydroxylase deficiency, each presenting with hypertension and hypokalemia in adulthood. In addition, 11-β hydroxylase deficiency cases showed precocious puberty with testicular adrenal rest tumor and adrenal myelolipoma, whereas the patient with 17-α hydroxylase deficiency showed sexual infantilism. Congenital adrenal hyperplasia is a rare cause of secondary hypertension in adults. It is particularly considered in patients with sexual maturation disorders, such as precocious puberty, delayed puberty, or sexual infantilism, and in those with hypertension and hypokalemia.

 

 

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EISSN 2822-6135