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ABSTRACT
It is important tosuspect and diagnose chronic diseases such as Diabetes Mellitus (DM) as early as possible. in the present study, erythrocyte Glucose-6-Phosphate Dehydrogenase (G-6-PD) and Superoxide Dismutase (SOD) levels, which are reported to be low in diabetic subjects, were measured in 10 patients with cryptogenic fatty liver, in 20 Type 2 diabetic patients with and without fatty liver and in 10 healthy subjects who did not have Impaired Glucose Tolerance (IGT) or DM history among their relatives. Peak serum insulin levels after oral glucose loading were reached at 30th minute in healthy subjects (141.68±122.5 µlU/ml) whereas at 60th minute in patients with cryptogenic fatty liver (147.94±91 µlU/ml). This difference was statistically significant for 60lh minute values (p<0.05). in addition basal serum insulin levels were subtracted from 60th and 120th minute serum insulin levels in both groups and thus insulin responses to glucose loading by time were determined. Differences in both 60th and 120th minute serum insulin levels between the basal levels in patients with cryptogenic fatty liver were significantly higher when compared with the subtracted values of healthy subjects (p<0.05 and p<0.05 for 60th and 120th minute respectively). Mean erythrocyte SOD (an antioxidant enzyme) activities in the cryptogenic fatty liver group and in diabetics without fatty liver were significantly lower than the activity measured in healthy subjects (p<0.005 and p<0.05 respectively). G-6-PD enzyme activity in all groups was similar (p>0.05 for all groups when compared with the control group). Either late insulin response to oral glucose loading or lower SOD enzyme activity found in patients with cryptogenic fatty liver suggested that fatty liver without a known etiologic factor might be a predictor of the very early phase of Type 2 DM. These results lead us to follow the patients with cryptogenic fatty liver more closely with regard to Type 2 DM which may develop later on.
It is important tosuspect and diagnose chronic diseases such as Diabetes Mellitus (DM) as early as possible. in the present study, erythrocyte Glucose-6-Phosphate Dehydrogenase (G-6-PD) and Superoxide Dismutase (SOD) levels, which are reported to be low in diabetic subjects, were measured in 10 patients with cryptogenic fatty liver, in 20 Type 2 diabetic patients with and without fatty liver and in 10 healthy subjects who did not have Impaired Glucose Tolerance (IGT) or DM history among their relatives. Peak serum insulin levels after oral glucose loading were reached at 30th minute in healthy subjects (141.68±122.5 µlU/ml) whereas at 60th minute in patients with cryptogenic fatty liver (147.94±91 µlU/ml). This difference was statistically significant for 60lh minute values (p<0.05). in addition basal serum insulin levels were subtracted from 60th and 120th minute serum insulin levels in both groups and thus insulin responses to glucose loading by time were determined. Differences in both 60th and 120th minute serum insulin levels between the basal levels in patients with cryptogenic fatty liver were significantly higher when compared with the subtracted values of healthy subjects (p<0.05 and p<0.05 for 60th and 120th minute respectively). Mean erythrocyte SOD (an antioxidant enzyme) activities in the cryptogenic fatty liver group and in diabetics without fatty liver were significantly lower than the activity measured in healthy subjects (p<0.005 and p<0.05 respectively). G-6-PD enzyme activity in all groups was similar (p>0.05 for all groups when compared with the control group). Either late insulin response to oral glucose loading or lower SOD enzyme activity found in patients with cryptogenic fatty liver suggested that fatty liver without a known etiologic factor might be a predictor of the very early phase of Type 2 DM. These results lead us to follow the patients with cryptogenic fatty liver more closely with regard to Type 2 DM which may develop later on.