Hyperprolactinemia in a Patient with Sheehan's Syndrome - Case Report

Abstract
Lactation failure is the first and the commonest manifestation of Sheehan's syndrome. We report the long-term follow-up of a patient with Sheehan's syndrome who presented with hyperprolactinemia rather than prolactin deficiency. A young woman developed Sheehan's syndrome after her 5th  delivery, which was associated with severe postpartum hemorrhage. She presented with central hypothyroidism, secondary adrenal insufficiency and growth hormone deficiency with preservation of gonadotroph function and complete empty sella on magnetic resonance imaging. In addition, she had hyperprolactinemia, which did not get corrected after thyroid hormone replacement. This is the first reported case of hyperprolactinemia in a patient with Sheehan's syndrome, in whom hyperprolactinemia persisted despite the adequate replacement for central hypothyroidism.