Endocrinology Research and Practice
Oral Presentation

Joint Involvement in Patients with Acromegaly and the Association Between Arthropathy and Disease Remission

1.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpasa Medical Faculty, İstanbul University, İstanbul, Turkey

2.

Department of Physical Therapy and Rehabilitation, Cerrahpasa Medical Faculty, İstanbul University, İstanbul, Turkey

3.

Colormed Imaging Center, İstanbul, Turkey

4.

Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, İstanbul University, İstanbul, Turkey

Endocrinol Res Pract 2018; 22: Supplement S5-S5
DOI: 10.25179/tjem.20182202-S31
Read: 1155 Downloads: 387 Published: 01 June 2018

Abstract

Aim: To evaluate joint complaints, physical examinations and X-rays of acromegalic patients and investigate association between arthropathy and disease remission and effects of arthropathy on quality of life.
Method: Acromegalic patients followed at Endocrinology clinic of Cerrahpasa Medical Faculty between 2015-2017 were screened. Demographic and disease status, physical examinations and quality of life scales (Acro-QoL) were recorded. The symptoms and examination findings of patients consulted with Rheumatology or Physical Therapy-Rehabilitation departments and X-rays were evaluated, retrospectively.
Results: Ninety-seven patients were assessed, 38 patients (F/M:31/7; p=0.006) had joint complaints and 59 (60.8%; F/M: 40/19; p>0.05) had pathological joint findings. Pathological joint signs were found in 30 patients with no symptoms, whereas 9 out of 38 patients who declared joint symptoms had no signs at rheumatological examination. Patients with symptoms and signs were older (47.6±11.5 vs 53.3±11.9; p=0.02 and 44.3±9.1 vs 53.4±12.3; p<0.001, respectively). When patients were evaluated according to remission status as remission with medical treatment (n=43), remission after surgery(n=27) and active disease (n=18); duration of disease in active disease group was shorter (p=0.01). Other parameters were similar between groups. There was a significant correlation between AcroQoL and shoulder and AcroQoL and small hand joints involvements (p=0.007, r=-0.2 vs p=0.004, r=-0.3), whereas no correlation was found between AcroQoL and knee or elbow involvements. No association found between disease duration and symptoms, examination findings, radiological findings or AcroQoL.
Conclusion: Joint degenerative changes detected in 60% of acromegalic patients, and affect quality of life, Regular evaluation of joint symptoms is recommended in the management of acromegalic patients.

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