Endocrinology Research and Practice
Case Report

Severe Lipodystrophy and Gynecomastia in a Male Patient on Lopinavir-based Second-line Antiretroviral Therapy


AIIMS, Department of Endocrinology and Metabolism, New Delhi


AIIMS, Department of Internal Medicine, New Delhi

Endocrinol Res Pract 2018; 22: 208-212
DOI: 10.25179/tjem.2017-56570
Read: 763 Downloads: 223 Published: 01 September 2018


With the introduction of highly active antiretroviral therapy, there has been a dramatic improvement in the clinical course of patients with human immunodeficiency virus infection and acquired immune deficiency syndrome. However, the favorable virological, immunological, and clinical profile of highly active antiretroviral therapy comes at the cost of some common and, at times, severe metabolic adverse effects such as dyslipidemia, body fat dysregulation/lipodystrophy, insulin resistance, and diabetes mellitus. We describe a case of a male patient from North India who developed similar adverse effects including gynecomastia while on the protease inhibitor lopinavir; the mention of such case is rare in the existing literature.



EISSN 2822-6135