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ABSTRACT
The aim of this study is to determine the relationships of triglyceride /HDL cholesterol ratio (THR) with ischemic heart disease (IHD) risk factors. 320 consecutive overweight and obese women were studied. Body mass index (BMI), waist/hip ratio (WHR), blood pressure, serum glucose, lipid profile, fasting insulin concentration, THR, and a surrogate of insulin resistance (homeostasis model assessment-HOMA) were determined. THR showed significant positive associations with total cholesterol, systolic blood pressure, WHR, BMI, insulin and HOMA. In multivariate regression analysis, total cholesterol, insulin and WHR were independent positive predictors of THR (R2 of the model = 0.1381, p<0.001). Receiver-operating characteristi c analysis indicated that cut-point of THR above which presence of previously defined risk factors will be increased was 4.5. Cut point of THR below which IHD risk will not be affected was 2.0. THR may be used as an indicator of the concurrent presence of IHD risk factors in obese women.
The aim of this study is to determine the relationships of triglyceride /HDL cholesterol ratio (THR) with ischemic heart disease (IHD) risk factors. 320 consecutive overweight and obese women were studied. Body mass index (BMI), waist/hip ratio (WHR), blood pressure, serum glucose, lipid profile, fasting insulin concentration, THR, and a surrogate of insulin resistance (homeostasis model assessment-HOMA) were determined. THR showed significant positive associations with total cholesterol, systolic blood pressure, WHR, BMI, insulin and HOMA. In multivariate regression analysis, total cholesterol, insulin and WHR were independent positive predictors of THR (R2 of the model = 0.1381, p<0.001). Receiver-operating characteristi c analysis indicated that cut-point of THR above which presence of previously defined risk factors will be increased was 4.5. Cut point of THR below which IHD risk will not be affected was 2.0. THR may be used as an indicator of the concurrent presence of IHD risk factors in obese women.