Acute Monocytic Leukemia with Pituitary Involvement: A Case Report

ABSTRACT

Central nervous system involvement is rare in acute myeloid leukemia (AML) cases. Pituitary involvement seems much more rarely with unknown frequency. A 29-year-old male patient was admitted to our clinic with the complaints of visual disturbance and poor performance status. His medical history revealed AML- M5 diagnosed five years ago and allogeneic hematopoietic stem cell transplantation performed in 2010. During follow-up in remission, his complaints had begun. In our clinic, the patient was diagnosed with AML M5 relapse associated with panhypopituitarism and central diabetes insipidus. Chemoradiotherapy was initiated immediately and hormone replacement therapy started due to hypopituitarism. His complaints partially resolved. He is still being followed up with intermittent intrathecal and systemic chemotherapy. Although rare, leukemic infiltration of the pituitary gland should be evaluated in leukemic patients with visual disturbance, hypopituitarism or central diabetes insipidus.