Comparison of Mental Health and Quality of Life in Euthyroid Patients Under Levothyroxine Mono-therapy Based on the Causes of Hypothyroidism

ABSTRACT

Objective: A controversy prevails regarding the adequacy of levothyroxine treatment in hypothyroid patients to reduce the risk of psychiatric illness, mood disorders and improve their quality of life. This study evaluated the relationship between different causes of hypothyroidism, mental health, and quality of life in patients treated with levothyroxine. Material and Methods: This cross-sectional study was performed on three groups of hypothyroid patients (Hashimoto thyroiditis, thyroidectomy, radioiodine therapy) treated with levothyroxine for at least six months, with the last thyroid-stimulating hormone within the normal range. After recording the demographic characteristics and thyroid hormone profiles, quality of life [12-item Short-Form Health Survey (SF-12)] and mental health [General Health Questionnaire 28 (GHQ-28)] were evaluated. Results: A total of 109 patients were evaluated in 3 groups of Hashimoto (48 patients), radioiodine therapy (15 patients), and thyroidectomy (46 patients). No significant difference was found between the 3 groups as evaluated by the total score of the SF-12 and GHQ- 28 questionnaires. The FT3/FT4 ratio was significantly correlated with five variables related to mental health and quality of life. Conclusion: The study did not find any association between the cause of hypothyroidism and psychological symptoms. However, a possible association between psychological symptoms and thyroid function status is suggested.