Turkish Journal of
Endocrinology and Metabolism
Original Article

Disease Activity is Associated with Depression and Anxiety in Cushing's Syndrome During COVID-19 Pandemic

1.

Clinic of Endocrinology and Metabolism, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, TURKEY

2.

Clinic of Psychiatry, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, TURKEY

Turk J Endocrinol Metab 2021; 25: 166-173
DOI: 10.25179/tjem.2021-82526
Read: 347 Downloads: 130 Published: 01 June 2021

ABSTRACT

Objective: To assess the depression and anxiety and their relationship with disease activity in patients with Cushing's syndrome (CS) in the coronavirus disease-2019 (COVID-19) pandemic. Material and Methods: This cross-sectional study included 54 patients with CS (48 females, 6 males). Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory (STAI)-State, STAI-Trait were used to evaluate scores and severity of depression, the current state of anxiety, and general anxiety, respectively. Patients with active CS (n=10) were recorded as group 1, those who were still receiving glucocorticoid replacement therapy after surgery (n=14) as group 2, and those in remission (n=30) as group 3. The groups were compared in terms of parameters that could affect anxiety and depression scores. Correlation analyses were also performed. Results: BDI-II scores were higher in group 1 than group 3 (p=0.002), and STAI-State scores were higher in group 1 than group 2 (p=0.03) while STAI-Trait scores and the other parameters were similar between the groups. Moderate and severe depression were detected in 60% of group 1, 25% of group 2, and 16% of group 3 patients. High state anxiety was seen in 70% of patients in group 1, 50% of group 2, and 57% of group 3 patients. Positive correlations between BDI-II scores and disease activity (r=0.438, p=0.001) and STAI-State scores and disease activity (r=0.297, p=0.029) were observed. Conclusion: Increased depression and state anxiety during the pandemic in patients with active CS suggests that psychiatric disorders may increase in those with a higher risk of severe COVID-19 disease.

 

 

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TURKISH
EISSN 1308-9846