Turkish Journal of
Endocrinology and Metabolism
Original Article

Levothyroxine Replacement is Acceptable in Patients With Above the Upper Normal Range Lipid Profiles and Subclinical Hypothyroidism - Original Article

1.

Zonguldak Karaelmas Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Zonguldak

2.

Trakya Üniversitesi Tıp Fakültesi, Endokrinoloji Bilim Dalı, Edirne, Turkey

3.

Istanbul University Istanbul Faculty of Medicine, Department of Endocrinology and Metabolic Diseases, Istanbul, Turkey

Turk J Endocrinol Metab 2006; 10: 0-0
Read: 143 Published: 01 December 2006

Abstract
Introduction: Subclinical hypothyroidism is a common disorder, particularly in middle-aged and elderly individuals. The aim of the present study was to determine the effect of L-thyroxine (LT4) substitution on serum lipid profile in patients with subclinical hypothyroidism (TSH > 4.5 μIU/mL and normal FT4).
Materials and Methods: Thirty-six female patients (mean age, 39 ± 9 yrs) with Hashimoto's thyroiditis were recruited in this study. The patients were separated into two groups according to their baseline lipid levels: group I, total cholesterol (TC)> 200 mg/dl (n=18); group II, low-density lipoprotein cholesterol (LDLc) >130 mg/dl (n=17). Thyroid hormone levels and lipid parameters were measured at baseline and after euthyroidism (TSH < 2.5 &mu;IU/mL) was achieved.
Results: Despite the fact that lipid profiles were not different between baseline and euthyroid conditions, TC and LDL levels were decreased significantly when euthyroidism was achieved (p<0.05) provided that the patients were separated into two groups according to their baseline lipid levels.
Discussion: TSH-guided LT4 therapy can improve lipid profile in patients with subclinical hypothyroidism if TC and/or LDLc levels were above the upper normal range.

 

TURKISH
ISSN 1301-2193 EISSN 1308-9846